Medications That May Cause Bone Loss

1. Synthetic Glucocorticoids
   Glucocorticoids are created by the body naturally as cortisone or cortisol. These are necessary for the body’s growth, metabolism, and response to physical stresses like injuries, infections, and inflammation. Synthetic glucocorticoids like prednisone are widely used as an effective anti-inflammatory drug.

   However, high levels of both synthetic and natural glucocorticoids are linked to the reduced activity of the bone-forming cells; raising the activity of the cells that break down bones. Bone damage usually results from the long-term intake of glucocorticoid pills.

2. Breast Cancer Drugs
   Aromatase inhibitors like anastrozole or Arimidex® are used for breast cancer. It has a property to prevent the production of estrogen; leading to extremely low blood levels of estrogen and causing bone loss.
3. Prostate Cancer Drugs
   A type of prostate cancer treatment called androgen deprivation therapy involves the removal of the source of the male sex hormone. This therapy is associated with reduced bone mineral density; resulting in an increased risk of bone fractures.
4. “Heartburn” Drugs
   Proton pump inhibitors like Prevacid® are used for the treatment of acid-associated conditions such as reflux and heartburn by reducing the amount of acid generated in the stomach.
   The long-term use of this drug at high doses may increase the risk of hip fractures in older adults due to insufficient calcium absorption from foods.
5. Anti-Seizure and Mood-Altering Drugs
   Anti-seizure drugs like carbamazepine are associated with a decrease in bone density because of low vitamin D and decreased calcium absorption.

   Additionally, medications that act on the central nervous system may cause falls due to confusion, drowsiness, low blood pressure, and other side effects. Also, antidepressants and sleep pills are linked to an increase in the risk of hip fractures.

These are only a few of a number of drugs that also increase the risk of bone loss. Talk to a Rheumatologist in Indiana for proper medication management.

At Rheumatology of Central Indiana, Dr. Tarek Kteleh can answer your inquiries about bone-related conditions, Rheumatoid Arthritis Treatment, and other Rheumatology Treatment in Muncie, Indiana.